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| Cat. Number | E6397 |
| Chemical Name | E6397 EPZ6438 1403254-99-8 |
| CAS Number | 1403254-99-8 |
| Mol. Formula | C34H44N4O4 |
| Mol. Weight | 572.74 |
| Qty 1 |
1mg |
| Qty 2 | 100mg |
| Appearance | white powder |
| Application Notes | ≥99% |
| Synonym | E7438, Tazemetostat, |
| Solubility | DMSO 5 mg/mL warmed (8.72 mM) Water Insoluble Ethanol Insoluble |
| Storage condition | -20°C |
| References | EPZ-6438 is an inhibitor of EZH2, a histone methyltransferase (HMT) responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. EPZ-6438 displays anticancer chemotherapeutic activity in in vivo models by inducing regression of malignant or atypical teratoid rhabdoid tumors containing altered or mutant SWI/SNF ATP-dependent chromatin remodelers. ReferencesKnutson SK, Warholic NM, Wigle TJ, et al. Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7922-7. PMID: 23620515. |
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