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| Cat. Number | T5060 |
| Chemical Name | T5060 TMP-269 1314890-29-3 |
| CAS Number | 1314890-29-3 |
| Mol. Formula | C25H21F3N4O3S |
| Mol. Weight | 514.52 |
| Qty 1 |
1mg |
| Qty 2 | 25mg |
| Application Notes | ≥98% |
| Solubility | DMSO 100 mg/mL (194.35 mM) Ethanol 2 mg/mL warmed (3.88 mM) Water Insoluble |
| Storage condition | -20°C |
| References | TMP-269 is an inhibitor of class II histone deacetylases (HDACs) that exhibits anticancer activity. In intestinal epithelial cells, TMP-269 inhibits cell cycle progression and cell proliferation. In multiple myeloma cells, this compound enhances carfilzomib-induced apoptosis. ReferencesKikuchi S, Suzuki R, Ohguchi H, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Mar 24. [Epub ahead of print]. PMID: 25801913. Sinnett-Smith J, Ni Y, Wang J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71. PMID: 24647541. |
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