V0144 N-VALERIC ACID 109-52-4
Clear and Colorless liquid
50mg/ml in water
n-Valeric acid is a low molecular weight carboxylic acid with a structure similar to γ-hydroxybutyrate (GHB) and γ-aminobutyric acid (GABA). This compound is found in Valeriana officinalis and is often used in the synthesis of esters. n-Valeric acid may also be produced by intestinal microflora and induces expression of Epstein-Barr virus-associated early antigen and viral capsid antigen in EBV-carrying human lymphoblastoid cells. Additionally, the α-keto-β-methyl derivative of n-valeric acid exhibits antioxidative activity, decreasing reactive oxygen species and lactate dehydrogenase in microglial cells under hypoxic or H2O2-stress-induced conditions. n-Valeric acid may inhibit histone deacetylases (HDAC).
Huang HM, Ou HC, Chen HL, et al. Protective effect of alpha-keto-beta-methyl-n-valeric acid on BV-2 microglia under hypoxia or oxidative stress. Ann N Y Acad Sci. 2005 May;1042:272-8. PMID: 15965072.
Huang HM, Zhang H, Ou HC, et al. alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores. Free Radic Biol Med. 2004 Dec 1;37(11):1779-89. PMID: 15528037.
Midtvedt AC, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first 2 years of human life. J Pediatr Gastroenterol Nutr. 1992 Nov;15(4):395-403. PMID: 1469519.