V0147 VALPROIC ACID SODIUM 1069-66-5
White Crystal Powder
Sodium 2-propylpentanoate, Sodium valproate, 2-Propylpentanoic acid sodium salt
Water (50 mg/ml) Ethanol (30 mg/ml) DMSO (5 mg/ml) DMF (5 mg/ml)
Valproic acid acts as an antagonist at T-type voltage-gated Ca2+ channels and voltage-gated Na+ channels; it also inhibits GABA transaminase, potentiating GABA signaling. Valproic acid is used clinically as an antiepileptic/anticonvulsant, although it also exhibits anti-inflammatory, anti-angiogenic, and anticancer chemotherapeutic activities. Valproic acid may also display antihypertensive benefit. In lung tissue, this compound prevents LPS-induced increases in TNF-α, IL-1β, NF-κB, NO, and iNOS. Valproic acid is an inhibitor of class I histone deacetylases (HDACs), primarily active against HDAC1, and downregulates expression of HDAC, VEGF, VEGFR2, and FGF, inhibiting tumor growth and angiogenesis in animal models.
Zhang ZH, Hao CL, Liu P, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2014 Feb;9(2):443-9. PMID: 24297248.
Ji MH, Li GM, Jia M, et al. Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. Inflammation. 2013 Dec;36(6):1453-9. PMID: 23846716.
Zhao L, Chen CN, Hajji N, et al. Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation. 2012 Jul 24;126(4):455-67. PMID: 22711276.
Rosenberg G. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 2007 Aug;64(16):2090-103. PMID: 17514356.
Kelly KM, Gross RA, Macdonald RL. Valproic acid selectively reduces the low-threshold (T) calcium current in rat nodose neurons. Neurosci Lett. 1990 Aug 14;116(1-2):233-8. PMID: 2175404.