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| Cat. Number | C9708 |
| Chemical Name | C9708 CYC-116 693228-63-6 |
| CAS Number | 693228-63-6 |
| Mol. Formula | C18H20N6OS |
| Mol. Weight | 368.46 |
| Qty 1 |
5mg |
| Qty 2 | 25mg |
| Appearance | Yellow Powder |
| Application Notes | ≥98% |
| Solubility | DMSO 24 mg/mL warmed (65.13 mM) Water Insoluble Ethanol Insoluble |
| Storage condition | -20°C |
| References | CYC-116 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer chemotherapeutic activity and is currently in clinical trials. CYC-116 inhibits proliferation of a variety of cancer cells. ReferencesKamei H, Jackson RC, Zheleva D, et al. An integrated pharmacokinetic-pharmacodynamic model for an Aurora kinase inhibitor. J Pharmacokinet Pharmacodyn. 2010 Aug;37(4):407-34. PMID: 20694801. Wang S, Midgley CA, Sca?rou F, et al. Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors. J Med Chem. 2010 Jun 10;53(11):4367-78. PMID: 20462263. |
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