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      1. 您的位置:首頁>>分析化學>>藥物分析標準品>>Z4900 ZM-447439 TRIHYDRATE 331771-20-1
        Cat. Number
        Z4900
        Chemical Name
        Z4900 ZM-447439 TRIHYDRATE 331771-20-1
        CAS Number
        331771-20-1
        Mol. Formula
        C29H31N5O4 ? 3H2O
        Mol. Weight
        567.63
        Qty 1
        1mg
        Qty 2
        25mg
        Appearance
        White to Off-white Powder
        Application Notes
        ≥99%
        Solubility
        DMSO 103 mg/mL (200.54 mM) Water Insoluble Ethanol Insoluble
        Storage condition
        -20°C
        References

        ZM-447439 inhibits aurora kinases A and B (AurA, AurB), preventing mitotic spindle formation and proper completion of mitosis. This compound exhibits anticancer activity, inducing hyperploidy and apoptosis in osteosarcoma cells and inhibiting growth in mesothelioma cells. ZM-447439 also induces apoptosis and inhibits expression of AurB and H3-P protein in cervical cancer cells, suppressing growth and survival.


        References

        Tavanti E, Sero V, Vella S, et al. Preclinical validation of Aurora kinases-targeting drugs in osteosarcoma. Br J Cancer. 2013 Nov 12;109(10):2607-18. PMID: 24129234.

        Baldini E, Tuccilli C, Prinzi N, et al. The dual Aurora kinase inhibitor ZM447439 prevents anaplastic thyroid cancer cell growth and tumorigenicity. J Biol Regul Homeost Agents. 2013 Jul-Sep;27(3):705-15. PMID: 24152827.

        Crispi S, Fagliarone C, Biroccio A, et al. Antiproliferative effect of Aurora kinase targeting in mesothelioma. Lung Cancer. 2010 Dec;70(3):271-9. PMID: 20371132.


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